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Dr Gibin Powathil

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Gibin Powathil
Senior Lecturer
Department of Mathematics
Swansea University
Swansea SA2 8PP
Talbot 210
+44 (0)1792 606255
+44 (0)1792 295843

Research Interests:

  • Cancer Modelling
  • Optimisation of cancer therapies
  • Modelling tumour microenvironment
**** Last updated on 12/02/2015, You may visit my new webpage at Swansea here****


  • G. Powathil, Modeling of brain tumors: effects of microenvironment and associated therapeutic strategies (PhD Thesis 2009)
  • G. Powathil, M. Kohandel, S. Sivaloganathan, A. Oza, M. Milosevic, Mathematical modeling of brain tumor: effects of surgery, radiotherapy and chemotherapy, Physics in Medicine and Biology 2007, 52:3291, doi: 10.1088/0031-9155/52/11/023
  • G. Powathil, M. Kohandel, S. Sivaloganathan, M. Milosevic, Modeling the Spatial Distribution of Chronic Tumor Hypoxia: Implications for Experimental and Clinical Studies, Computational and Mathematical Methods in Medicine 2012, Article ID 410602, doi: 10.1155/2012/410602
  • G.G. Powathil, K.E. Gordon, L.A. Hill, M.A.J. Chaplain, Modelling the effects of cell-cycle heterogeneity on tumour response to chemotherapy: Biological insights from a hybrid multi-scale cellular automaton model, Journal of Theoretical Biology 2012,308:1, doi: 10.1016/j.jtbi.2012.05.015
  • G.G. Powathil, A. Thompson, M.A.J. Chaplain, The role of cellular heterogeneity on the therapeutic response of breast cancer: Clinical insights from a hybrid multiscale computational model , Published Abstract, Cancer Research 2012, 72(S24):P5-05-02, doi:10.1158/0008-5472.SABCS12-P5-05-02
  • G.G. Powathil, D.J.A. Adamson, M.A.J. Chaplain, Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: Clinical insights from a computational model , PLOS Computational Biology 2013, 9(7):e1003120, doi:10.1371/journal.pcbi.1003120
  • G.G. Powathil, M.A.J. Chaplain, M. Swat, Systems Oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling , Seminars in Cancer Biology 2014, doi:10.1016/j.semcancer.2014.02.003
  • G.G. Powathil, M.A.J. Chaplain, Hybrid multiscale approach in cancer modelling and treatment prediction, Contributed book chapter, Mathematical Oncology 2014, A. D'onofrio and A. Gandolfi (editors), Birkhauser (to appear), ISBN:978-1-4939-0457-0
  • M.A.J. Chaplain, G.G. Powathil Multiscale modelling of cancer progression and treatment control: Role of intracellular heterogeneities in chemotherapy treatment, Biophysical Reviews and Letters, doi:10.1142/S1793048015500058
  • Y. Kim, G.G. Powathil, H. Kang, D. Trucu, H. Kim, S. Lawler, M.A.J. Chaplain, Strategies of eradicating glioma cells: A multi-scale mathematical model with miR-451-AMPK-mTOR control, PLOS ONE 10(1), e0114370, doi:10.1371/journal.pone.0114370
  • G.G. Powathil, A.J. Munro, M.A.J. Chaplain, M. Swat, Bystander effects and its implications in radiation therapy: Clinical insights from the multiscale in silico experiments (under revision)
  • G.G. Powathil, M.A.J. Chaplain, M. Swat, Investigating the development of chemotherapeutic drug resistance in cancer: A multiscale computational study, IET Systems Biology (under revision)
  • Y. Kim, H. Kang, G.G. Powathil, H. Kim, D. Trucu, W. Lee, S. Lawler, M.A.J. Chaplain, The role of miR-451-AMPK-mTOR in regulation of cell proliferation and infiltration, Interface (submitted)

Teaching 2010/2011, 2011/2012, 2012/2013: